Will Cooper Kupp get over 30 fantasy points in a rivalry against the 49ers? Can Brandon Aiyuk keep up his solid production vs. the Rams? What about George Pickens vs. Darius Slay and the Eagles?

1. Cooper Kupp, Rams vs. 49ers

It doesn’t matter who he is playing, Cooper Kupp will always produce at an elite level. The most consistent player in Fantasy Football, Kupp had 14 receptions the last time he played the 49ers.

2. Ja’Marr Chase, Bengals vs. Browns

Ja’Marr Chase is coming off of back-to-back 32+ fantasy point performances and his connection with Joe Burrow is back.

3. Stefon Diggs, Bills vs. Packers

4. Justin Jefferson, Vikings vs. Cardinals

Justin Jefferson is averaging 22.1 fantasy points per game on the year and the Cardinals certainly don’t have a shutdown cornerback. Expect Jefferson to return from the bye week motivated, fresh, and dominant.

6. Tyreek Hill, Dolphins vs. Lions

6. Davante Adams, Raiders vs. Saints

7. Mike Evans, Buccaneers vs. Ravens

8. DeAndre Hopkins, Cardinals vs. Vikings

DeAndre Hopkins caught 10 passes for 103 yards in his return against the Saints. The Vikings rank 19th in pass defense so Hopkins is due for another strong showing.

9. Jaylen Waddle, Dolphins vs. Lions

10. Deebo Samuel, 49ers vs. Rams

11. CeeDee Lamb, Cowboys vs. Bears

12. Amon Ra St. Brown, Lions vs. Dolphins

13. Michael Pittman Jr., Colts vs. Commanders

14. Gabe Davis, Bills vs. Packers

Gabe Davis was on fire before the Bills entered the bye week catching three touchdowns in three games. Davis is due for yet another big day if Josh Allen continues to target him.

15. Brandon Aiyuk, 49ers vs. Rams

If it wasn’t for Deebo Samuel’s epic performance against the Rams in week 4 Brandon Aiyuk would be ranked ahead of him based on production. Over the past 2 games, Aiyuk has caught 16 passes for 166 yards and 2 touchdowns and the Rams don’t have anyone to shut him down beside Ramsey (who will be on Samuel in man coverage). Unless Jimmy Garoppolo all of a sudden stops throwing to Aiyuk, he is due for another big fantasy performance.

16. A.J. Brown, Eagles vs. Steelers

17. Tyler Lockett, Seahawks vs. Giants

18. Amari Cooper, Browns vs. Bengals

19. Tee Higgins, Bengals vs. Browns

20. George Pickens, Steelers vs. Eagles