Angels right-hander pitcher, Griffin Canning delivered an impressive performance, but it wasn’t enough to hold off the Cleveland Guardians.

Canning threw six strong innings, but struggling Jose Ramirez hit a go-ahead two-run home run in the bottom of the sixth, leading the Guardians to a 4-1 victory on Sunday at Progressive Field.

Canning (1-4) retired 11 batters in a row until Josh Naylor hit a single to center in the bottom of the fourth inning. Naylor, who hit a grand slam on Saturday, went on to hit a two-run home run to right center in the bottom of the eighth inning.

The Angels were in control early behind Canning’s strong start, but Ramirez’s bat took over, resulting in the only mistake Canning made all game.

After winning the opening game of the three-game series, the Angels lost the next two, bringing their season record to 12-22.

Here are three takeaways from the game:

Angels silent again

Nolan Schanuel didn’t have much luck in the last two games going 0 for 7, after hitting a solo home run on Friday night.

In the series finale, Guardians right-hander Carlos Carrasco (2-2) pitched six solid innings to lead his team to a win over the Angels. He allowed six hits and struck out three batters.

Carrasco, who gave up one run and two walks, was helped by relievers Scott Barlow and Tim Herrin, who pitched two scoreless innings before Emmanuel Clase closed the ninth for his 10th save.

Angels third baseman Cole Tucker went 2 for 2 with a double and a single on first-pitch swings. He is 5 for 12 since being called up from Triple-A Salt Lake.

Zach Neto struggled at the beginning of the season, hitting only .167 in his first 21 games. However, in his last 12 games, Neto has been batting .366 and was 1 for 2 on Sunday.

On Sunday, the Angels managed one run, which was scored by Willie Calhoun on Joe Adell’s sacrifice fly. The Angels finished with six hits to the Guardians’ five.

Canning started well

During his seventh start, Canning demonstrated excellent command over his fastball and slider, shutting down the Guardians’ lineup throughout the early innings. He threw 57 strikes out of 87 pitches.

Canning permitted four hits, issued one walk and recorded five strikeouts. It was arguably his best start of the season because of his improved control.

The Los Angeles Angels have lost 13 out of their last 16 games, with their only series win this year coming against the Miami Marlins.

What’s next for Angels?

It seems like the Angels are struggling to maintain a consistent offensive performance. And that’s with Mike Trout out of the lineup for a while because of knee surgery.

However, by the time Trout returns the Angels might be out of the AL West race.

Logan O’Hoppe was unable to play because of a right hand contusion sustained Saturday, but he expects to return Monday. Luis Rengifo, who had been experiencing an illness, was absent from the lineup for the second consecutive day, but reported feeling better.

The Los Angeles Angels open a three-game series Monday in Pittsburgh with left-hander Tyler Anderson (2-3, 2.23 ERA) on the mound against the Pirates right-hander Mitch Keller (2-3, 5.18).